List of Validated Bioanalytical Methods at XBL
Compound (Metabolite) Matrix Sample Volume Calibration Range
1'-Hydroxybufuralol (OH-buf) Microsome 0.2 mL 1-200 nM
1'-Hydroxymidazolam (OH-Mid) Microsome 0.2 mL 10-2000 nM
4'-Hydroxydiclofenac (OH-Dic) Microsome 0.2 mL 50-10000 nM
4'-Hydroxymephenytoin (OH-Mep) Microsome 0.2 mL 50-10000 nM
6-Hydroxychlorzoxazone (OH-Chl) Microsome 0.2 mL 50-10,000 nM
6α-Hydroxypaclitexel (OH-Pac) Microsome 0.2 mL 5-1000 nM
6β-Hydroxytestosterone (OH-Tes) Microsome 0.2 mL 100-20,000 nM
Abamectin Sheep Plasma 200 L 0.5-300 ng/mL
Acetaminophen (Ace) Microsome 0.2 mL 50-10000 nM
Albuterol Human Plasma 0.4mL or 0.45mL 2-600 pg/mL or 2-1000 pg/mL
Amprenavir Rat Plasma 50 L 10 - 5000 ng/mL
Antipyrine Buffer (HBSS) 100 L 50-12500 nM
Atenolol Buffer (HBSS) 100 L 5-2500 nM
Atovastatin, 2-OH atovastatin, 4-OH atovastatin Human Plasma 100 L 0.25-100 ng/mL
Beclomethasone Rat Plasma 100 L 0.5-200 ng/mL
Beclomethasone Dipropionate and Beclomethasone-17-Propionate Human Plasma 500 L 10-2500 (BDP), 20-5000 pg/mL (17-BMP)
Beclomethasone Dipropionate and Beclomethasone-17-Propionate Human Plasma 200 L 10-2500 (BDP), 20-5000 pg/mL (17-BMP)
Budesonide Human Plasma 500 L 10-2000 pg/mL
Buprenorphine/Norbuprenorphine Human Plasma 100 L 25-1250/50-2500 pg/mL
Buprenorphine/Norbuprenorphine Human Urine 200 L 50-2500/100-5000 pg/mL
C4 Human Plasma 100 L 50-50,000 pg/mL
Caffeine and paraxanthine Human Plasma 50 L 25-10,000 ng/mL
Calcipotriene Human Plasma 100 L 1-500 ng/mL
Carbamazepine and Carbamazepine-10,11-epoxide Human Plasma 50 L 20-5,000 ng/mL for carbamazepine, and 10-2,500 ng/mL for Carbamazepine-10,11-epoxide
Citalopram Human Plasma 1 mL 0.2-100 ng/mL
Clopidogrel/Clopidogrel Carboxylic Acid/Aspirin Human Plasma 200 L 0.5-100 ng/mL /10-2000 ng/mL/monitor
Clozapine Human Plasma 1 mL 0.2-20 ng/mL
Cyclosporine A Human Blood 50 L 5 - 1000 ng/mL
Decitabine Human Plasma 200 L 1-100 ng/mL
Desirudin Human Plasma 500 L 5-3000 ng/mL
Dexamethasone Human Plasma 50 L 1-1000 ng/mL
Dextromethorphan and Dextrorphan Human Plasma 50 L 0.1 - 50 ng/mL for Dextromethorphan, 1 - 500 ng/mL for Dextrorphan
Dextromethorphan and Dextrorphan Human Plasma 50 L 0.1 - 50 ng/mL
Digoxin Human Plasma 250 L 10-5000 pg/mL
Digoxin Human Urine 250 L 1-500 ng/mL
Digoxin Buffer (HBSS) 100 L 10-10000 nM
Diltiazem, N-Desmethyl Diltiazem and Desacetyl Diltiazem Human Plasma 50 L 2 - 1000 ng/mL for Diltiazem, 0.5 - 250 ng/mL for N-Desmethyl Diltiazem and Desacetyl Diltiazem
Docetaxel Docetaxel M2 and Docetaxel M4 Human Plasma 50 L 0.2-200 ng/mL
Efavirenz Human Plasma 50 L 10 - 5000 ng/mL
Eptifibatide Human Plasma 200 L 2.5-500 ng/mL
Florfenicol Amine Beef Muscle NA 0.025 to 0.5 ppm
Fluconazole Human Plasma 50 L 10-5000 ng/mL
Fluticasone Propionate Human Plasma 1 mL 3~1000 pg/mL
Fluticasone Propionate Human Plasma 1 mL 3~100 pg/mL
Fluticasone Propionate Human Plasma 150 L 2 - 200 pg/mL
Fluticasone Propionate Human Plasma 500 L 0.4 - 200 pg/mL
Fluticasone Propionate Human Plasma 0.6 mL 1 - 200 pg/mL
Fluvoxamine Human Plasma 50 L 0.5-500 ng/mL
Formoterol Human Urine 2 mL(Method I), 1mL(Method II) 10~1250 pg/mL
Formoterol Human Plasma 500 L 0.4-100 pg/mL
Formoterol Human Plasma 500 L 0.4~40 pg/mL
Glimepiride Human Plasma 1 mL 0.2~100 ng/mL
Glipizide Human Plasma 400 L 2~500 ng/mL
Glucose Human Plasma 100 L 0.1 - 5 mg/mL
Guanfacine Human Plasma 500 L 0.05-20 ng/mL
Hydroxybupropion (OH-Bup) Microsome 0.2 mL 5-1000 nM
Iohexol Human Serum 50 L 0.5 - 250 mg/mL
Irinotecan SN-38 Mouse, Rat Plasma NA 0.05-25 ng/mL for low range and 50-15000 ng/mL for high range
Ketoconazole Human Plasma 50 L 20-5,000 ng/mL
Ketorolac (R&S) Human Plasma 500 L 10-1000 ng/mL (Ketorolac) 0.1~50 ng/mL (ORG-41793)
Labetalol Buffer (HBSS) 100 L 50-10000 nM
Leuprolide Dog Serum 200 L 0.1-50 ng/mL
Leuprolide Rat Serum 100 L 0.1~50 ng/mL
Leuprolide Human Serum 500 L/100 L 0.05~50 ng/mL/0.1~50 ng/mL
Leuprolide Rat Serum 100 L 0.1 - 50 ng/mL
Lisdexamgetamine Human Plasma 100 L 1-250 ng/mL for Lisdexamfetamine, 2-500 ng/mL for Amphetamine
Metformin Human Plasma 100 L 5 - 2500 ng/mL
Metformin Human Urine 100 L 5 - 2500 ng/mL
Metformin Human Urine 50 L 5 - 2500 mg/mL
Methotrexate, 7 Hydroxy Methotrexate Human Urine 100 L 1~500 ng/mL
Midazolam and 1-OH Midazolam Human Plasma 100 L 0.1 - 20 ng/mL
Moxifloxacin Human Plasma 50 L 20-4000 ng/mL
Naftifine Human Plasma 200 L 0.02-10 ng/mL
Naftifine Mini-Pig Plasma 200 L 0.05-35 ng/mL
Naftifine Human Urine 200 L 1-1000 ng/mL
N-desethylamodiaquine Microsome 100 L 25-10000 nM
Nebivolol (chiral) Rat Plasma 100 L 0.05-20 ng/mL
Nebivolol (chiral) Mouse Plasma 100 L 0.05-20 ng/mL
Nebivolol (chiral) Dog Plasma 100 L 0.05-20 ng/mL
Nebivolol (chiral) Guinea Pig Plasma 100 L 0.05-20 ng/mL
Nebivolol (Total) Mouse Plasma 100 L 0.05-20 ng/mL
Nebivolol (Total) Rat Plasma 100 L 0.05-20 ng/mL
Nebivolol (Total) Dog Plasma 100 L 0.05-20 ng/mL
Nebivolol (Total) Guinea Pig Plasma 100 L 0.05-20 ng/mL
octreotide Rat Plasma 200 L 0.05-25 ng/mL
Omeprazole and 5-OH Omeprazole Human Plasma 50 L 2 - 1000 ng/mL
Ondansetron Human Plasma 1 mL 0.1-100 ng/mL
Orntide Human Serum 200 L 0.1-50 ng/mL
Orntide Rat Serum 100 L 1-500 ng/mL
Oxycodone/Noroxydodone/oxymorphone/noroxymorphone Human Plasma 250 L 0.1-10 ng/mL/0.1-10 ng/mL/0.02-2 ng/mL/0.1-10 ng/mL
Oxytetracycline Tissues Bovine, Sheep NA 0.5-120 ng/mL
Paclitaxel Human Plasma 100 L 1-250 ng/mL
Paclitaxel Rat Plasma 100 L 01214: 1-250 ng/mL; 03203: 0.2-100 ng/mL and 0.2-2000 ng/mL
Paclitaxel Human Plasma 100 L 1-1000 ng/mL
Paclitaxel Human Plasma 100 L 1-1000 ng/mL
Paclitaxel, 6-α- and 3p-hydroxypaclitaxel Human Plasma 200 L 1-200/0.25-50/0.25-50 ng/mL
Paliperidone Human Plasma 100 L 0.1-40 ng/mL
Palmitic Acid, Linoleic Acid, and Oleic Acid Human Plasma 50 L 10-500 g/mL
p-Aminohippuric Acid Human Urine 50 L 0.2 - 100 mg/mL
p-Aminohippuric Acid Human Plasma 50 L 0.2 - 100 mg/mL
Paroxetine Human Plasma 200 L 0.1-50 and 1-500 ng/mL
Prazosin Buffer (HBSS) 100 L 5-2500 nM
Propion and Naltrexone Human Plasma 50 L 0.2-100 ng/mL
Pyrimethamine Human Plasma 100 L 1-200 ng/mL
Quinidine Buffer (HBSS) 100 L 10-10000 nM
Repaglinide Human Plasma 200 L 0.02 - 10 ng/mL
Ribavirin Human Plasma 100 L 5-500 ng/mL
Rifampicin Human Plasma 50 L 20 - 4000 ng/mL
Risperidone and 9-OH Risperidone Rat Plasma 100 L 0.1-50 ng/mL
Risperidone and 9‑OH Risperidone Human Plasma 100 L 0.1-50 ng/mL
Salmeterol Human Plasma 500 L 4-800 pg/mL
Salmeterol Human Plasma 200 L 4 - 800 pg/mL
Salmeterol Human Plasma 500 L 0.5 - 250 pg/mL
Sertaconazole Rat Plasma 100 L 0.01-7.5 ng/mL
Sertraline and venlafaxine Human Plasma 50 L 1-500 ng/mL
Sulphasalazine and Sulfapyridine Human Plasma 50 L 10.0 to 10,000 ng/mL for Sulphasalazine, and 10.0 to 5,000 ng/mL for Sulfapyridine
Telbivudine Human Plasma 100 L 10-5000 ng/mL
Terbinafine Human Plasma 1 mL 0.1-50 ng/mL
Testosterone Rat serum 100 L 50-10,000 pg/mL
Thalidomide Monkey, Rabbit Plasma 100 L 5-1000 ng/mL
Tin-Mesoporphyrin Human Plasma 100 L 5-500 ng/mL
Tin-Mesoporphyrin Rabbit Plasma 100 L 10-5000 ng/mL
Tin-Mesoporphyrin Rat Plasma, Dog Plasma 100 L (dog) 50L (rat) 10~5000 ng/mL
Tin-Mesoporphyrin Human, Dog, Rat Plasma 100 L 5-1000 ng/mL for human, 5-50000 ng/mL for dog and rat
Tiotropium Bromide Human Plasma 500 L 0.2- 100 pg/mL
Tiotropium Bromide Human Plasma 500 L 0.5 - 250 pg/mL
Tiotropium Bromide Human Urine 100 L 10 - 5000 pg/mL
Tolbutamide, Hydroxy Tolbutamide and 4-Carboxy Tolbutamide Human Plasma 50 L 100 - 50000 ng/mL for Tolbutamide, 2.5 - 1250 ng/mL for Hydroxy Tolbutamide, 5 - 2500 ng/mL for 4-Carboxy Tolbutamide
Triamcinolone Placebo 200 L 5-250 and 250-5000 ng/mL
Triclosan Human Plasma, Urine 100 L 10-300 ng/mL, 300-2000 ng/mL
Verapamil Human Plasma 100 L 1 - 500 ng/mL
Virginiamycin Porcine liver, kidney, muscle and fat/skin NA 25-1000 ppb
Zolpidem Human Plasma 1 mL 0.1~20 ng/mL
β-Estradiol 3-β-D-glucuronide Microsome 0.2 mL 1-500 nM
7 Analyte-Combo Assay (Ace+OH-Buf+OH-Dic+OH-Mep+OH-Mid+OH-Tes+OH-Bup) Microsome 0.2 mL Ace+OH-Dic (50-10,000); OH-Buf (1-200); OH-Mid (10-2000); OH-Mep+OH-Bup (5-1000); OH-Tes (100-20,000)