XBL * A subsidiary of Lab Testing Division, WuXi AppTec Inc. WuXi AppTec XBL * A subsidiary of Lab Testing Division, WuXi AppTec Inc. WuXi AppTec
Thursday, July 27, 2017

List of Validated LC-MS/MS Bioanalytical Methods at XBL

 

Compound (Metabolite)

Matrix

Sample Volume

Calibration Range

9-NC and 9-AC

Human Urine

2 mL

0.2 - 20 ng/mL

9-NC and 9-AC

Rat Plasma

100 uL

0.5 - 50 ng/mL

9-NC and 9-AC

Rabbit Plasma

250 uL

0.5 - 50 ng/mL

9-NC and 9-AC

Dog Plasma

500 uL

0.2 - 20 ng/mL

9-NC and 9-AC

Human Plasma

500 uL

0.2 - 20 ng/mL

Abamectin

Sheep Plasma

200 uL

0.5 - 300 ng/mL

Acetaminophen

In Vitro Media

200 uL

50 - 10000 nM

Albuterol

Human Plasma

400 uL

2 - 600 pg/mL

Amprenavir

Rat Plasma

50 uL

10 - 5000 ng/mL

Beclomethasone

Rat Plasma

100 uL

0.5 - 200 ng/mL

Beclomethasone Dipropionate and Beclomethasone-17-Propionate

Human Plasma

200 uL

10 - 2500 (BDP), 20 - 5000 pg/mL (17-BMP)

Beclomethasone Dipropionate and Beclomethasone-17-Propionate

Human Plasma

500 uL

10 - 2500 (BDP), 20 - 5000 pg/mL (17 - BMP)

 Budesonide

Human Plasma

500 uL

10 - 2000 pg/mL

Caffeine and paraxanthine

Human Plasma

50 µL

25 - 10,000 ng/mL

Carbamazepine and Carbamazepine-10,11-epoxide

Human Plasma

50 µL

20 - 5,000 ng/mL for Carbamazepine, and 10 - 2,500 ng/mL for Carbamazepine-10,11-epoxide

Citalopram

Human Plasma

1 mL

0.2 - 100 ng/mL

Clopidogrel/Clopidogrel Carboxylic
Acid/Aspirin

Human Plasma

200 uL

0.5 - 100 ng/mL /10 - 2000 ng/mL/monitor

Clozapine

Human Plasma

1 mL

0.2 - 20 ng/mL

Cyclosporine A

Human Blood

50 uL

5 - 1000 ng/mL

Decitabine

Human Plasma

200 uL

1 - 100 ng/mL

Desirudin

Human Plasma

500 uL

5 - 3000 ng/mL

Dextromethorphan and Dextrorphan

Human Plasma

50 uL

0.1 - 50 ng/mL for Dextromethorphan, 1 - 500 ng/mL for Dextrorphan

Diltiazem, N-Desmethyl Diltiazem and Desacetyl Diltiazem

Human Plasma

50 uL

2 - 1000 ng/mL for Diltiazem, 0.5 - 250 ng/mL for N-Desmethyl Diltiazem and Desacetyl Diltiazem

Efavirenz

Human Plasma

50 uL

10 - 5000 ng/mL

Eptifibatide

Human Plasma

200 uL

2.5 - 500 ng/mL

Florfenicol Amine

Beef Muscle

NA

0.025 to 0.5 ppm

Fluticasone Propionate

Human Plasma

1 mL

3 - 1000 pg/mL

Fluticasone Propionate

Human Plasma

1 mL

3 - 100 pg/mL

Fluticasone Propionate

Human Plasma

600 uL

1 - 200 pg/mL

Fluticasone Propionate

Human Plasma

150 uL

2 - 200 pg/mL

Fluticasone Propionate

Human Plasma

500 µL

0.4 - 200 pg/mL

Fluvoxamine

Human Plasma

50 µL

0.5 - 500 ng/mL

Formoterol

Human Urine

2 mL(Method I), 1mL(Method II)

10 - 1250 pg/mL

Formoterol

Human Plasma

500 uL

0.4 - 100 pg/mL

Formoterol

Human Plasma

500 uL

0.4 - 40 pg/mL

Glimepiride

Human Plasma

1 mL

0.2 - 100 ng/mL

Glipizide

Human Plasma

400 uL

2 - 500 ng/mL

Glucose

Human Plasma

100 uL

0.1 - 5 mg/mL

Guanfacine

Human Plasma

500 uL

0.05 - 020 ng/mL

Iohexol

Human Serum

50 uL

0.5 - 250 mg/mL

Irinotecan, SN-38*

Mouse, Rat Plasma

100 mL

0.05 - 25 ng/mL for low range and 50 - 15000 ng/mL for high range

Ketoconazole

Human Plasma

50 µL

20 - 5,000 ng/mL

Ketorolac (R&S)

Human Plasma

500 uL

10 - 1000 ng/mL (Ketorolac) 0.1 - 50 ng/mL (ORG-41793)

Leuprolide

Dog Serum

200 uL

0.1 - 50 ng/mL

Leuprolide

Rat Serum

100 uL

0.1 - 50 ng/mL

Leuprolide

Human Serum

500 uL/100 & uL

0.05 - 50 ng/mL/0.1 - 50 ng/mL

Lisdexamgetamine Human Plasma

100 uL

1-250 ng/mL for Lisdexamfetamine, 2-500 ng/mL for Amphetamine

Metformin

Human Plasma

100 uL

5 - 2500 ng/mL

Metformin

Human Urine

100 uL

5 - 2500 ng/mL

Metformin

Human Urine

50 uL

5 - 2500 mg/mL

Methotrexate, 7 Hydroxy Methotrexate

Human Urine

100 uL

1 - 500 ng/mL

Midazolam and 1-OH Midazolam

Human Plasma

100 uL

0.1 - 20 ng/mL

Moxifloxacin Human Plasma

50 uL

20-4000 ng/mL

Naftifine

Human Plasma

200 uL

0.02 - 10 ng/mL

Naftifine

Mini-Pig Plasma

200 uL

0.05 - 35 ng/mL

Naftifine

Human Urine

200 uL

1 - 1000 ng/mL

Nebivolol (chiral)

Rat Plasma

100 uL

0.05 - 20 ng/mL

Nebivolol (chiral)

Mouse Plasma

100 uL

0.05 - 20 ng/mL

Nebivolol (chiral)

Dog Plasma

100 uL

0.05 - 20 ng/mL

Nebivolol (chiral)

Guinea Pig Plasma

100 uL

0.05 - 20 ng/mL

Nebivolol (Total)

Mouse Plasma

100 uL

0.05 - 20 ng/mL

Nebivolol (Total)

Rat Plasma

100 uL

0.05 - 20 ng/mL

Nebivolol (Total)

Dog Plasma

100 uL

0.05 - 20 ng/mL

Nebivolol (Total)

Guinea Pig Plasma

100 uL

0.05 - 20 ng/mL

Octreotide*

Rat Plasma

200 µL

0.05 - 25 ng/mL

Omeprazole and 5-OH Omeprazole

Human Plasma

50 uL

2 - 1000 ng/mL

Ondansetron

Human Plasma

1 mL

0.1 - 100 ng/mL

Orntide

Human Serum

200 uL

0.1 - 50 ng/mL

Orntide

Rat Serum

100 uL

1 - 500 ng/mL

Oxycodone/Noroxydodone/
oxymorphone/noroxymorphone

Human Plasma

250 uL

0.1 - 10 ng/mL/0.1 - 10 ng/mL/0.02-2 ng/mL/0.1 - 10 ng/mL

Oxytetracycline

Tissues Bovine, Sheep

NA

0.5 - 120 ng/mL

Paclitaxel

Human Plasma

100 uL

1 - 250 ng/mL

Paclitaxel

Rat Plasma

100 uL

01214: 1 - 250 ng/mL; 03203: 0.2 - 100 ng/mL and 0.2 - 2000 ng/mL

Paclitaxel

Rat Plasma

100 uL

1 - 1000 ng/mL

Paclitaxel

Human Plasma

100 uL

1 - 1000 ng/mL

Paclitaxel, 6-alpha - and3' p-hydroxypaclitaxel Human Plasma

200 uL

1-200/0.25-50/0.25-50 ng/mL

Paliperidone

Human Plasma

100 uL

0.1 - 40 ng/mL

p -Aminohippuric Acid

Human Urine

50 uL

0.2 - 100 mg/mL

p -Aminohippuric Acid

Human Plasma

50 uL

0.2 - 100 mg/mL

Paroxetine

Human Plasma

200 uL

0.1 - 50 and 1 - 500 ng/mL

Pyrimethamine

Human Plasma

100 uL

1 - 200 ng/mL

Repaglinide

Human Plasma

200 uL

0.02 - 10 ng/mL

Ribavirin

Human Plasma

100 uL

5 - 500 ng/mL

Rifampicin

Human Plasma

50 uL

20 - 4000 ng/mL

Risperidone and 9-OH Risperidone*

Rat Plasma

100 µL

0.1 - 50 ng/mL

Salmeterol

Human Plasma

200 uL

4 - 800 pg/mL

Salmeterol

Human Plasma

500 uL

4 - 800 pg/mL

Salmeterol

Human Plasma

500 uL

0.5 - 250 pg/mL

Sertaconazole

Rat Plasma

100 uL

0.01 - 7.5 ng/mL

Sulphasalazine and Sulfapyridine

Human Plasma

50 uL

10.0 - 10,000 ng/mL for Sulphasalazine and 10.0 to 5,000 ng/mL for Sulfapyridine

Telbivudine

Human Plasma

100 uL

10 - 5000 ng/mL

Terbinafine

Human Plasma

1 mL

0.1 - 50 ng/mL

Testosterone* Rat Serum

100 uL

50 - 10,000 pg/mL

Thalidomide

Monkey, Rabbit Plasma

100 uL

5 - 1000 ng/mL

Tin-Mesoporphyrin

Human Plasma

100 uL

5 - 500 ng/mL

Tin-Mesoporphyrin

Rabbit Plasma

100 uL

10 - 5000 ng/mL

Tin-Mesoporphyrin

Rat Plasma, Dog Plasma

100 uL (dog) 50 uL (rat)

10 - 5000 ng/mL

Tin-Mesoporphyrin

Human, Dog, Rat Plasma

100 uL

5 - 1000 ng/mL for human, 5 - 50000 ng/mL for dog and rat

Tiotropium Bromide

Human Plasma

500 uL

0.5 - 250 pg/mL

Tiotropium Bromide

Human Urine

100 uL

10 - 5000 pg/mL

Tolbutamide, Hydroxy Tolbutamide and 4-Carboxy Tolbutamide

Human Plasma

50 uL

100 - 50000 ng/mL for Tolbutamide, 2.5 - 1250 ng/mL for Hydroxy Tolbutamide, 5 - 2500 ng/mL for 4 - Carboxy Tolbutamide

Triamcinolone

Placebo

200 uL

5 - 250 and 250 - 5000 ng/mL

Triclosan

Human Plasma, Urine

100 uL

10 - 300 ng/mL, 300 - 2000 ng/mL

Verapamil

Human Plasma

100 uL

1 - 500 ng/mL

Virginiamycin

porcine liver, kidney, muscle and fat/skin

NA

25 - 1000 ppb

Zolpidem

Human Plasma

1 mL

0.1 - 20 ng/mL

4'-Hydroxydiclofenac (OH-Dic)

In Vitro Media

200 uL

50 - 10000 nM

4'-Hydroxymephenytoin (OH-Mep)

In Vitro Media

200 uL

50 - 10000 nM

1'-Hydroxybufuralol (OH-buf)

In Vitro Media

200 uL

1 - 200 nM

1'-Hydroxymidazolam (OH-Mid)

In Vitro Media

200 uL

10 - 2000 nM

6 beta -Hydroxytestosterone (OH-Tes)

In Vitro Media

200 uL

100 - 20,000 nM

Hydroxybupropion (OH-Bup)

In Vitro Media

200 uL

5 - 1000 nM

6-Hydroxychlorzoxazone (OH-Chl)

In Vitro Media

200 uL

50 - 10,000 nM

6 alpha -Hydroxypaclitexel (OH-Pac)

In Vitro Media

200 uL

5 - 1000 nM

7 Analyte-Combo Assay (Ace+OH-Buf+OH-Dic+OH-Mep+OH-Mid+OH-Tes+OH-Bup)

In Vitro Media

200 uL

Ace+OH-Dic (50-10,000); OH-Buf (1-200); OH-Mid (10-2000); OH-Mep+OH-Bup (5-1000); OH-Tes (100-20,000)

* Qualified only