XBL * A subsidiary of Lab Testing Division, WuXi AppTec Inc. WuXi AppTec XBL * A subsidiary of Lab Testing Division, WuXi AppTec Inc. WuXi AppTec
Thursday, May 25, 2017

In Vitro Metabolism and Stability Studies

  • Study types
    • - Metabolic stability
    • - Metabolite profiling and ID (cold or radio-labeled)
    • - Chemical stability, Pro-drug and Chiral inversion monitoring
  • Test systems
    • - Microsomes
    • - Hepatocytes
    • - S9 fractions
    • - Whole blood, plasma, buffers
  • Interspecies comparison
    • - Mouse
    • - Rat
    • - Rabbit
    • - Dog
    • - Monkey
    • - Human

Bulk metabolite isolation and purification can be conducted upon request to obtain samples sufficient for further spectral investigation (i.e., 1-D and 2-D 1H and 13C NMR).

Protein binding studies (hot or cold)

  • Equilibrium dialysis
  • Utrafiltration
  • Multiple species plasma, alpha-1 acid glycoprotein

Whole blood/plasma partitioning studies for most species