XBL * A subsidiary of Lab Testing Division, WuXi AppTec Inc. WuXi AppTec XBL * A subsidiary of Lab Testing Division, WuXi AppTec Inc. WuXi AppTec
Thursday, July 27, 2017

In vivo – ADME/DMPK

WuXi/XBL maintains AAALAC-accredited animal facilities. We are equipped to conduct in-life studies in rat (intact or bile/jugular vein cannulated) and mouse. WuXi/XBL provides comprehensive radiolabel (3H or 14C) ADME study support across non-clinical species. WuXi/XBL has implemented the Debra LIMS system to guide ADME study conduct and analysis. Study types include:

  • Mass balance
  • Tissue distribution (necropsy or QWBA)
  • Lacteal secretion, placental transfer
  • Metabolite radioprofiling and identification
  • Pharmacokinetic (single or multiple dose/formulation screening)
  • Cassette PK
  • Drug-drug interaction, knockout models
  • Metabolism p450 enzyme induction
  • Bioavailability screening for various routes of administration