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Wednesday, November 22, 2017

Publications

"Absorption, distribution, metabolism, and excretion of [14C]-dasotraline in humans" Yu-Luan Chen, Estela Skende, Jing Lin, Yijun Yi, Peter L. Wang, Sarah Wills, H. Scott Wilkinson, Kenneth S. Koblan and Seth C. Hopkins. Published in Pharmacology Research and Perspectives, Volume 5, Issue 1, e00281

"A Sensitive LC-MS/MS Method for Quantitation of Naltrexone and 6ß-Naltrexol in Human Plasma (1 pg/mL)" Dawei Zhou, Shaoting Zhang, Thomas Moran, Mohamed A. Osman, and Xinping Fang. Presented at the American Society for Mass Spectrometry 64th ASMS Conference, San Antonio, Texas, June 2016

"A Novel Approach to Minimize the Matrix Effect in the Development of LC-MS/MS Method for Quantitation of Buprenorphine and Norbuprenorphine in Human Urine" Dawei Zhou, Shu Zhang, Pei Li, Xuejun Sun, Mohamed A. Osman, and Xinping Fang. Presented at the American Society for Mass Spectrometry 64th ASMS Conference, San Antonio, Texas, June 2016

"Different Approach for Improvement of Low Recovery Dried Blood Spot Storage Sample and Its Application in BioanalyticalAssay" Dawei Zhou, John Ma, Mohamed A. Osman, and Xinping Fang. Presented at the American Society for Mass Spectrometry 64th ASMS Conference, San Antonio, Texas, June 2016

"Species-Specific Red Blood Cell Partitioning of a Test Drug: Elucidation of the Selective Binding to Rat β2 Globin of a Test Drug" Heasook Kim-Kang, Yijun Yi, and Philip Inskeep. Presented at the 11th International ISSX Meeting, Busan, Korea, June 2016

"Total Residue Depletion and Metabolism of [2-14C]Enrofloxacin in the Milk of Lactating Dairy Cows" Heasook Kim-Kang, Yijun Yi, and Harish M. Chopade. Presented at the 11th International ISSX Meeting, Busan, Korea, June 2016

"Significant Sulfate Metabolite Formation of WX-1 Ex Vivo with Human K2EDTA Blood, Minor in Human Na-Heparin Blood and Human K2EDTA Plasma , and Absent in Rat or Dog K2EDTA Plasma and Blood" Wang, P., Phan, P., Liu, B., Kim-Kang, H., Fang, X., and Wu, J. Presented at the 20th North American ISSX Meeting, Orlando, FL, October 2015

"Analytical Method for the Determination of a Major Residue with a Zwitterionic nature of a Fluoroquinolone Antimicrobial Drug in Bovine Milk Using HPLC with Fluorescence Detection" Kim-Kang, H.,and Chopade, H. Presented at the 20th North American ISSX Meeting, Orlando, FL, October 2015

"A Sensitive LC-MS/MS Method for Quantitation of Buprenorphine and Norbuprenorphine in Human Plasma" Zhou, D., Zhang, D., Fang, X. The ASMA Meeting, 2015.

"A Sensitive LC-MS/MS Method for Quantitation of Digoxin (10 pg/mL) in Human Plasma" Zhou, D., Wuyi, Z., Runlan, H., Fang, X. The ASMA Meeting, 2015.

"A Novel LC-MS/MS Method for Quantitation of GLS409 in Rat Plasma" Zhou, D., Manik, D., Heasook, K., Sherman, M., Wright, G., Yanachkov, I., Fang, X. The ASMA Meeting, 2015.

"A Sensitive LC-MS/MS Method for Quantitation of 7α-hydroxy-4-cholesten-3-one in Human Plasma" Zhou, D., Yang, X., Manik, D., Fang, X. The ASMA Meeting, 2015.

"Drug Metabolism and Disposition, 42(5): 890-898, May 2014" Takahashi,R., Shuguang,M., Alan,D., Qin Yue, Heasook,K.,Yijun,Y., Michael,S.,Hunt.K., Kallan,N., Cornelis E.C.A. Hop,and S. Khojasteh,C., 2014.

"Quantitative Whole Body Autoradiography (QWBA) Analysis Reveals that CPX-351 Shifts the Exposure of Cytarabine (Cyt) and Daunorubicin (Daun) Away from Many Tissues While Providing Prolonged Exposure to Cytotoxic Drug Concentrations in the Bone Marrow Compared to Conventional Free Drug Administration" Mayer, L., Sadowski, N., Tardi, P., Xie, X., Cabral-Lilly, D., Heller, D. The 56th ASH Meeting, San Francisco, CA, December 2014.

"CPX-351 Markedly Reduces Renal and Hepatic Clearance Rates for Cytarabine (Cyt) and Daunorubicin (Daun) in Rats with an Associated Decrease in Excretory and Metabolic Burden Despite Providing Dramatic Increases in Systemic Drug Exposure Compared to Conventional Cyt+Daun" Mayer, L., Fulton. J., Kim-Kang, H., Yi, Y., Wang, P., Tardi, P., Xie, X., Heller, D. The 56th ASH Meeting, San Francisco, CA, December 2014.

"In Vivo Rat Metabolism of an Acute Myeloid Leukemia (AML) Drug CPX-351 (Cytarabine:Daunorubicin) Liposome Injection," Kim-Kang, H., Yi, Y., Wang, P., Tardi, P., Xie, S., Mayer, L. The 19th North American ISSX Meeting, San Francisco, CA, October 2014.

"A Novel LC-MS/MS Method for Quantitation of Three Fatty Acids in Human Plasma," Zhou, D., Chien, D.S., Yang, X., Fang, X., Wu, J. The 62nd ASMS Conference, Baltimore, MD, June 2014.

"An Extremely Sensitive LC-MS/MS Method for Quantitation of Fluticasone Propionate (0.4 pg/mL) in Human Plasma," Fang, X., Zhou, D., Wu, J. The 62nd ASMS Conference, Baltimore, MD, June 2014.

"Application of In-Source Fragmentation for More Accurate Metabolite Semi-quantification by Peak Area from High-Resolution Mass Spectrometry," Chen, L., Fang, X., Wu, J., Wang, P. The 62nd ASMS Conference, Baltimore, MD, June 2014.

"Biotransformation and Mass Balance of Faldaprevir, A Hepatitis C NS3/NS4 Protease Inhibitor In Rats" Linzhi Chen, Roger St. George, Stephen H. Norris, Yanping Mao, Elsy Philip, Li-Quan Wang, Diana Wu, and Michael J. Potchoiba. Xenobiotica, Early Online: 1-12, 2014

"Dose-dependent Exposure and Metabolism of GNE-892, a ß-secretase Inhibitor, in Monkeys: Contributions by P450, AO, and P-gp," Takahashi, R., Shuguang M., Yue, Q., Kim-Kang, H., Yi, Y., Lyssikatos J., Regal K., Hunt, K., Kallan, N., Siu, M., Hop, C., Liu, X., and Khojasteh, S. European Journal of Drug Metabolism and Pharmacokinetics, 39:1-17, April 2014

"In Vivo Rat Metabolism of an Obesity Drug Beloranib," Kim-Kang,H., Yi, Y., Inskeep, P., and Vath, J., The 10th International ISSX Meeting, Toronto, ON, Canada, October 2013.

"Evaluation of 4B-Hydroxycholesterol as an Endogenous Biomarker of CYP3A in Cynomolgus Monkeys," Li k., Zhang, L., Wu, X., Shu, P., Wang, Y.,  Feng, H., Gu, Z., Hsu, H.H.,  and  Zhao, S., The 10th International ISSX Meeting, Toronto, ON, Canada, October 2013.

"Radiolabeled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary," White, R.E., Evans, D.C., Hop, C.E.C.A., Moore, D.J., Prakash, C., Surapaneni, S., Tse, F.L.S. Xenobiotica, 43(2): 219-225, February 2013.

Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration,” Hoffman, M., Kasserra, C., Reyes, J., Schafer, P., Kosek, J., Capone, L., Parton, A., Kim-Kang, H., Surapaneni, S., Kumar, G., Cancer Chemotherapy and Pharmacology, December 2012.

Unique Biotransformation from Pyrimidine to Pyrazole Derivatives in Rats – Its Isolation/Identification by LC/MS and NMR,” Kim-Kang, H., Y, Y., White, R., Takahashi, R., Siu, M., Liu, X., Khojasteh, C., and Yue, Q., The 18th North American ISSX Meeting, Dallas, TX, October 2012.

"An Ultra Sensitive LC-MS/MS Method for Quantitation of Salmeterol (LLOQ, 0.5 pg/ML) in Human Plasma," Zhou, D., Fang, X., Zhang, S., Coopersmith, B., and Wu, J., APA Conference, Baltimore, MD, Sept. 2012.

Metabolic and Pharmacokinetic Differentiation of STX209 and Racemic Baclofen in Humans," Sanchez-Ponce, R., Wang, L.Q., Lu, W., von Hehn J., Cherubini, M., and Rush, R., Metabolites, 2, 596-613, 2012.

"Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938," Niu, C.,.… ,Wang, L.Q., Chao, P.B., et al., Antimicrobial Agents and Chemotherapy, 56(7): 3767-3775, 2012.

"Application of In-Source Fragment Ion Filtering in Drug Metabolite Profiling and Identification by High-Resolution Mass Spectrometry," Wang, L., Fang, X., and Wu, J., The 60th ASMS Conference, Vancouver, Canada, May 2012.

"A Sensitive LC-MS/MS Method for the Quantitation of Fluticasone Propionate (1 pg/mL) in Human Plasma," Zhou, D., Ji, A.J., Zhang, S., Fang, X., and Wu, J., The 60th ASMS Conference, Vancouver, Canada, May 2012.

"Mass Defect Filter - A New Tool to Expedite Screening and Dereplication of Natural Products and Generate Natural Product Profiles," Gu Z.M., Wang L.Q., and Wu J., The Natural Products Journal 1(2): 135-145, 2011.

"Disposition, Metabolism and Mass Balance of [14C] Apremilast Following Oral Administration," Hoffmann, M., Kumar, G., Schafer, P., Cedzik, D., Capone, L., Fong, K-L., Gu, Z., Heller, D., Feng, H., Surapaneni, S., Laskin, O., and Wu, A., Xenobiotica 41(12): 1063-1075, 2011.

"Investigation of SEP-227900 metabolites in Humans from the First-in-Man Study Samples by LC-MS and NMR," Chen, Y., Skende, E., Maier, G., Wang, L., and Gu, Z., 2011 AAPS Annual Meeting, Washington, DC, October 2011.

Identification and Determination of the Percent AUC of Five Metabolites of a Tetrahydropyran-containing Drug, Co-eluting as a Broad Peak due to the Presence of Metabolites Undergoing Conformational Change during HPLC Radiochromatography,” Kim-Kang, H., The 17th North American ISSX Meeting, Atlanta, GA, October 2011.

"Investigation of Incurred Sample Reanalysis Failure in Sample Analysis for Human Urine P-Aminohippuric Acid and Metformin," Ji, A.J., Morris, A., Doda, K., Huo, R., Zhou, D., and Fang, X., The 12th Annual Land O' Lakes Bioanalytical Conference, Madison, WI, July 2011.

"Introduction of Commonly used Low Energy Radioisotopes (C-14, H-3, and I-125) in Life-Science R&D," Wu, J., Drug Metabolism and Pharmacokinetics International Workshop – Application of Low Energy Radioisotopes in Life Science R & D, Nanjing, China, June 2011, Oral Presentation.

"Why and When Do We Need to Perform Radiolabeled Studies?" White, R., Drug Metabolism and Pharmacokinetics International Workshop – Application of Low Energy Radioisotopes in Life Science R & D, Nanjing, China, June 2011, Oral Presentation.

"Application of Radioisotopes in Quantitative Whole Body Autoradiography (QWBA)," Linehan, S., Drug Metabolism and Pharmacokinetics International Workshop – Application of Low Energy Radioisotopes in Life Science R & D, Nanjing, China, June 2011, Oral Presentation.

"Fundamentals of Drug Discovery and Development," White, R., Drug Metabolism and Pharmacokinetics International Workshop – Application of Low Energy Radioisotopes in Life Science R & D, Nanjing, China, June 2011, Oral Presentation.

"An LC-MS/MS Method for Simultaneously Determining Formoterol and Budesonide in Human Plasma with Dual HPLC System," Fang, X., Zhai, L., and Zhou, D., The 59th ASMS Conference, Denver, Co, June 2011.

"Validation of A Surrogate Derivative LC/MS/MS Method for the Determination of Glucose in Human Plasma with [13C6] D-Glucose as a Tracer," Zhou, D., Xie, F., and Gu, Z., The 59th ASMS Conference, Denver, Co, June 2011.

"Liquid Extraction Surface Analysis Mass Spectrometry (LESA MS): Drug Distribution and Metabolism of Diclofenac in Mouse," Prosser, S.J., Eikel, D., Linehan, S.T., Murphy, K., Heller, D., Rudewicz, P.J., and Henion, J.D., The 59th ASMS Conference, Denver, Co, June 2011, Oral Presentation.

"Recommendations on: Internal Standard Criteria, Stability, Incurred Sample Reanalysis and Recent 483s by the Global CRO Council for Bioanalysis," Heller, D., et al., Bioanalysis, 1323-1332, March 2011.

"Determination and Confirmation of Tulathromycin Residues in Bovine Liver and Porcine Kidney via Their Common Hydrolytic Fragment Using High-Performance Liquid Chromatography/Tandem Mass Spectrometry," Boner, P.L., Gottschall, D.W., and Kim-Kang, H., Journal of AOAC International, Vol. 94, No. 2, 2011.

Challenges in Urine Bioanalytical Assays: Overcoming Nonspecific Binding,” Ji, A.J., et al., Bioanalysis, 2(9), 1573-1586, 2010.

"Comparative in vitro Metabolism of Benzyl Amine Containing Test Drug Using Human, Rat, and Dog Plasma – Investigation of Amine Oxidase Involvement in Drug Metabolism," Kim-Kang, H., and Gu, Z., 9th International ISSX Meeting, September 2010, Istanbul, Turkey; Drug Met. Reviews, 42(Suppl. 1), 337, 2010.

"Application of 19F NMR to Mass Balance Studies," Wang, L., Desai, M., and Gu, Z., 9th International ISSX Meeting, September 2010, Istanbul, Turkey; Drug Met. Reviews, 42(Suppl. 1), 337, 2010.

"Mass Defect Filtering: a New Tool to Expedite Screening, Dereplication and Identification of Natural Products," Gu, Z., Wang, L., The 58th ASMS Conference, Salt Lake City, UT, May 2010.

"A Selective and Sensitive LC-MS/MS Method for the Determination of Beclomethasone Dipropionate and Beclomethasone-17-Propionate in Human Plasma," Fang, X., Zhou, D., Liang, W., Gu, Z., The 58th ASMS Conference, Salt Lake City, UT, May 2010.

"Accurate Measurement of Biopolymer Molecular Weight with Orbitrap Mass Spectrometer," Zhou, D., Gu, Z., The 58th ASMS Conference, Salt Lake City, UT, May 2010.

"Application of Radioisotopes in Drug Absorption, Distribution, Metabolism and Excretion (ADME) Studies and General Metabolism Related Investigations," Gu, Z., Wu, D., Lau, J., Kim-Kang, H., Linehan, S., Wang, L., Kartha, J.S., Fang, X., Feng, H., Heller, D., and Wu, J., Asian Journal of Pharmacodynamics and Pharmacokinetics, 10(2): 123-135, March 2010.

"Application of Radioisotopes in Drug Absorption, Distribution, Metabolism and Excretion Studies," Gu, Z., Fang, X., Feng, H., and Wu, J., Asian Journal of Pharmacodynamics and Pharmacokinetics, 10(1): 11-18, March 2010.

"Formation of a Global Contract Research Organization Council for Bioanalysis," Fang, X., et.al., Bioanalysis, 1797-1800, February 2010.

"Structural Determination of By-Products Obtained in Acetylation of Cysteine and Cysteine-Conjugated Metabolites by LTQ-Orbitrap XL � Leading to the Establishment of an Alternative Esterification and Amidation Method," Gu, Z., Wang, L., The 57th ASMS Conference, Philadelphia, PA, June 2009.

"A Sensitive LC-MS/MS Method for the Determination of KX2-391 in Human Plasma," Fang, X., Zhou, D., Pham, A.., Hangauer, D., Wu, J., The 57th ASMS Conference, Philadelphia, PA, June 2009.

"A Rapid LC-MS/MS Method for the Determination of Telbivudine in Human Plasma," Zhou, D., Jiang, X., Fang, X., The 57th ASMS Conference, Philadelphia, PA, June 2009.

"Comparative Metabolism of 14C-Labeled Apixaban in Mice, Rats, Rabbits, Dogs, and Humans," Zhang, D., He, K., Raghavan, N., Wang, L., Mitroka, J., Maxwell, B., Knabb, R., Frost, C., Schuster, A., Hao, F., Gu, Z., Humphreys, W.G., Grossman, S. DMD 37:1738–1748, 2009.

"Structure Elucidation by Synthesis of Four Metabolites of the Antitumor Drug ENMD-1198 Detected in Human Plasma Samples," Fang, Z., Agoston, G.E., Ladouceur, G., Treston, A.M., Wang, L.Q., and Cushman, M., Tetrahedron, 65(51), 10535-10543, 2009.

"Metabolism and Excretion of PRT060128, a New Competitive, Reversible P2Y12 Inhibitor, in Healthy Human Subjects," Hutchaleelaha, A., Ye, C., Lambing, J., Desai, M., Gu, Z., Kissling, C.J., Romanko, K., Liu, H.D., and Gretler, D., 2008 AAPS Annual Meeting, Atlanta, GA, November 2008.

"Comprehensive Investigation of Injection Time and Auto Gain Control on Ion Trap Instruments for the LC-MS Application of Metabolite Identification," Gu, Z., Bachalis, D., Ming, G., The 56th ASMS Conference, Denver, CO, June 2008.

"A Rapid and High Sensitive LC-MS/MS Method for Quantitation of Budesonide in Human Plasma," Zhou,G., Zhou, D., Fang, X., and Wu, J., The 56th ASMS Conference, Denver, CO, June 2008.

"Quantification of a Polypeptide Drug, Desirudin, in Human Plasma Using Electrospray LC-MS/MS with an Analog Polypeptide as Internal Standard," Wenzhong, L., Fang, X., and Wu, J., and Yu, T., The 56th ASMS Conference, Denver, CO, June 2008.

"A High Sensitive LC-MS/MS Method for Quantitation of Formoterol in Human Plasma," Zhou, D., Wenzhong, L., Fang, X., and Wu, J., The 56th ASMS Conference, Denver, CO, June 2008.

"A Sensitive LC-MS/MS Method for Quantitation of Ribavirin in Human Plasma," Fang, X., Zhou, W., Arriola, K., and Wu, J., The 56th ASMS Conference, Denver, CO, June 2008.

"Preclinical Characterization of Intestinal Absorption and Metabolism of Promising Anti-Alzheimer's Dimer Bis(7)-tacrine," Zhang, L., Yu, H., Li, W., Cheung, M., Pang, Y., Gu, Z., Chan, K., Wang, Y., Zuof, Z., Fan Hang, Y., International Journal of Pharmaceutics, 357(1-2): 85–94, June 2008.

"Physicochemical Properties and the In Vivo AChE Inhibition of Two Potential Anti-Alzheimer Agents, Bis(12)-hupyridone and Bis(7)-tacrine," Yu, H., Kan, K.K.W., Ho, J.M.K., Li, W.M., Carlier, P.R., Pang, Y.P., Gu, Z., Chan, K.K.C., Wang, Y.T., and Han, Y.F., Journal of Pharmaceutical and Biomedical Analysis, 46(1): 75-81, January 2008.

"Comparative In Vitro Metabolism of 14Cciclesonide in Hepatocytes from the Mouse, Rat, Rabbit, Dog and Human," Gu, Z., Zhao, X.G., Nave, R., Liu, D.D.W., Feng, H., Wu, J., Howell, S.R., and King, S., American Journal of Therapeutics, 14(3):280-290, May/June 2007.

"Ciclesonide Disposition and Metabolism I. Comparative In Vitro Metabolism of 14Cciclesonide in Hepatocytes from the Mouse, Rat, Rabbit, Dog and Human," Gu, Z., Zhao, X.G., Nave, R., Liu, D.D.W., Feng, H., Wu, J., Howell, S.R., and King, S., American Journal of Therapeutics, 14(3):280-290, May/June 2007.

"Automatic Generation of Extract ion Chromatogram for Mass Spectral Peaks with Specific Isotope Labeled Patterns," Ma, M., Gu, Z., Gu, M. and Wang, Y., The 55th ASMS Conference, Indianapolis, IN, June 2007.

"Development of a High Performance Liquid Chromatography-Tandem Mass method for Determination of Bis(7)-tacrine, a Promising Anti-Alzheimer's Dimer, in Rat Blood," Yu, H., Kan, K.K.W., Ho, J.M.K., Li, W.M., Carlier, P.R., Pang, Y.P., Gu, Z., Chan, K.K.C., Wang, Y.T., and Han, Y.F., Journal of Pharmaceutical and Biomedical Analysis, 44(5): 1133-1188, May 2007.

"Ciclesonide Disposition and Metabolism II. Pharmacokinetics, Metabolism, and Excretion in the Mouse, Rat, and Dog," Guo, Z., Howell, S.R., and Gu, Z., American Journal of Therapeutics, 13(6):490-501, November/December 2006.

"Mass Balance, Metabolism, and Excretion of Rambazole, a Novel Retinoic Acid Metabolism-Blocking Agent (RAMBA) in Mice, Rats, and Dogs," Gu, Z., Wu, D., Feng, H., and Barrett, D., The 14th North American ISSX Meeting, Puerto Rico, October, 2006; Drug Met. Reviews, Vol. 38 (Suppl. 2.) 176, 2006.

"Sensitive and Rapid Method for the Determination of (R,R)-Formoterol and (S,S)-Formoterol in Human Plasma Using Chiral Liquid Chromatography-Tandem Mass Spectrometry," Gu, Z., Zhou, D., Huo, M., Hsu, R., and Maier, G., 2006 AAPS Annual Meeting, San Antonio, TX, October 2006.

"Reduction of Nitriles to Amines in Positive Ion Electrospray Ionization Mass Spectrometry," Gu, Z., Ma, J., Zhao, X.G., and Wu, J., Rapid Communications in Mass Spectrometry, 20: 2969-2972, 2006.

"Determination of In Vivo Chiral Inversion of (R,R)-Formoterol to its Stereosiomers, (S,S)-Formoterol, (R,S)-Formoterol, and (S,R)-Formoterol, by Highly Sensitive and Specific LC/MS/MS Methods in Human Plasma," Gu, Z., Zhou, D., Huo, M., Hsu, R., Hsu, R., Maier, G., New England Drug Metabolism Discussion Group Summer Symposium, June, 2006.

"A New LC/MS/MS Method for Quantitation of Moxifloxacin in Human Plasma," Li, Y.X. and Zhou, D., The 54th ASMS Conference, Seattle, WA, May 2006.

"A Highly Sensitive and Specific LC/MS/MS Method for Quantitation of Methotrexate and Its 7-Hydroxy Metabolite in Human Plasma," Li, Y.X. and Zhou, D., The 54th ASMS Conference, Seattle, WA, May 2006.

"Automated and Parameter-Free Peak Integration for LC/MS/MS Quantitation," Gu, M., Zhou, D., Gu, Z.M., and Wang, Y., The 54th ASMS Conference, Seattle, WA, May 2006.

"Reduction of Nitriles to Amines in Positive Ion Electrospray Ionization Mass Spectrometry," Ma, J. and Gu, Z.M., The 54th ASMS Conference, Seattle, WA, May 2006.

"LC/MS Chiral Methods and Its Application in Bioanalysis," Zhou, D., Li, Y.X and Gu, Z.M., The 54th ASMS Conference, Seattle, WA, May 2006.

"Accurate Mass Filtering of Ion Chromatograms for Metabolite Identification using a Unit Mass Resolution Liquid Chromatography/Mass Spectrometry System," Gu, M., Wang, Y., Zhao, X., and Gu, Z., Rapid Communications in Mass Spectrometry, 20: 764-770, 2006.

"Combining Profile Mode Mass Spectral Data Processing and Accurate Mass Filtering (AMF) for LC/MS Metabolite Applications," Zhao, X.G., Gu, Z., Gu, M., and Wang, Y., The 53rd ASMS Conference, San Antonio, TX, May 2005.

"Accurate Mass Measurements on Unit Mass Resolution Mass Spectrometers," Gu, M., Wang, Y., Zhao, X.G., and Gu, Z., The 53rd ASMS Conference, San Antonio, TX, May 2005.

"Differential Metabolism of Benzhydrolpiperidines in the Rat," ElNaggar, S.F., McLaughlin, T., Creekmore, R.W., Henrie, R., Wu, D., and Wu, J., ACS Agrochemicals Division meeting, San Diego, CA, March 2005.

"Pharmacokinetics, Metabolism, and Excretion of Ciclesonide after Intravenous and Oral Administration of 14CCiclesonide in Mice, Rats, Rabbits, and Dogs," Guo, Z., Howell, S., Gu, Z., Chen, K., Rohatagi, S., Cai, L., Wu, J., Stuhler, J., and King, P., 2004 AAPS Annual Meeting, Baltimore, MD, November 2004.

"In Vitro Metabolism of 14CCiclesonide in Hepatocytes from Mice, Rats, Rabbits, Dogs, and Humans," Gu, Z., Howell, S., Liu , D.D.W., Zhao, X., Feng, H., Wu, J., King, S.P., 2004 AAPS Annual Meeting, Baltimore, MD, November 2004.

"A Highly Sensitive and Specific LC/MS/MS Method (0.5 pg/mL) for Quantitation of (R/R)/(S,S)Formoterol and (R,S)/(S,R)Formoterol in Human Plasma and Urine," Zhou, D., Huo, M., Caruso, J., Zhou, G., Potenza, L., Hsu, R.S.H., and Li, Y., The 52nd ASMS Conference, Nashville, TN, May 2004.

"Loss of Hydroxyl Radical (•OH) in CID MS/MS for Identification of Oxidative Drug Metabolites," Zhao, X., Ma, J., Feng, H., and Gu, Z., The 52nd ASMS Conference, Nashville, TN, May 2004.

"Metabolism and Pharmacokinetics of Carfentrazone-Ethyl in the Rat," ElNaggar, S.F., McCarty, J.D., Froelich, L.W., Wu, D., and Chemidlin, J., ACS Agrochemicals Division meeting, Anaheim, CA, March-April 2004.

"Metabolism and Disposition of F7967 in the Rat," ElNaggar, S.F., Zhang, J. Creekmore, R.W., Letinski, D., Curry, S.J., Goudar, J., Wang, G., Wu, D., and Gu, Z., ACS Agrochemicals Division meeting, Anaheim, CA, March-April 2004.

"Tissue Distribution, Metabolism, and Residue Depletion Study in Atlantic Salmon Following Oral Administration of [3H]Emamectin Benzoate," Kim-Kang, H., Bova, A., Crouch, L.S., Wislocki, P.G., Robinson, R.A., and Wu, J., J. Agric. Food Chem., 52(7): 2108-2118, 2004.

"Determination of Flunixin in Edible Bovine Tissues Using Liquid Chromatography Coupled with Tandem Mass Spectrometry," Boner, P.L., Liu, D.D.W., Feely, W.F., Robinson, R.A., Wu, J., J. Agric. Food Chem., 51(26): 7555-7559, 2003.

"Mass Balance Study of 14C-Nebivolol in Humans with Different CYP2D6 Genotypes," Chien, C., Liang, D., Gu, Z., Robinson, R.A., Wu, J., and Huang, M., 2003 AAPS Annual Meeting, Salt Lake City, UT, October 27-30, 2003.

"Determination of (R,R)-Formoterol Inversion Products in Human Plasma and Urine By Chiral and Achiral-LC/MS/MS," Gu, Z., Zhao, X., Maier, G., Hsu, R.H.S., 2003 AAPS Annual Meeting, Salt Lake City, UT, October 27-30, 2003.

"Metabolism Study of 14C-Nebivolol in Humans with Different CYP2D6 Genotypes," Gu, Z., Robinson, R., Cai, L., Wu, J., Duncan, J., Owens, W., Liang, D., Huang, M., O'Donnell, J., 2003 AAPS Annual Meeting, Salt Lake City, UT, October 2003.

"Tissue Distribution, Metabolism, and Residue Depletion Study in Atlantic Salmon Following Oral Administration of 3H-Emamectin Benzoate," Kim-Kang, H., The 12th North American ISSX Meeting, October 12-16, 2003, Providence, RI; Drug Met. Reviews, Vol. 35 (Suppl. 2.) 222, 2003.

"Determination and Confirmation of 5-Hydroxyflunixin in Raw Bovine Milk Using Liquid Chromatography Tandem Mass Spectrometry," Boner, P., Liu, D.D.W., Feely, W.F., Wisocky, M.J., and Wu, J., J. Agric. Food Chem., 51: 3753-3759, 2003.

"Flunixin Residues in Milk after Intravenous Treatment of Dairy Cattle with 14CFlunixin," Feely, W.F., Chester-Yansen, C., Thompson, K., Campbell, J.W., Boner, P.L., Liu, D.D.W., and Crouch, L.S., J. Agric. Food Chem., 50(25): 7308-7313, 2003.

"Simultaneous Determination of the Enantiomers of Ketorolac As Well As XBL011003 in Human Plasma with LC/MS," Li, Y., Schmidt, E., Huo, M., Zhou, G., Wu, J., and Zhou, D., The 51st ASMS Conference, Montreal/Quebec, Canada, June 2003.

"A Highly Sensitive and Specific LC/MS/MS Method (3 pg/mL) for Quantitation of Fluticasone Propionate in Human Plasma," Zhou, D., Zhou, G., Scotto, C., Caruso, J., Wu, J., and Li, Y., The 51st ASMS Conference, Montreal/Quebec, Canada, June 2003.

"Biotransformation of [14C] BMS275183 in Bile-Duct Cannulated (BDC) Rats," Comezoglu, N., Kim-Kang, H., Ogan, M., and Everett, D., The 11th North American ISSX Meeting, October 2002, Orlando, FL; Drug Met. Reviews, Vol. 34 (Suppl. 1.) 65, 2002.

"Metabolism of [14C] BMS275183 in Mouse, Rat, Dog, Monkey and Human Liver Microsomes," Kim-Kang, H., Comezoglu, N., Ogan, M., and Everett, D., The 11th North American ISSX Meeting, October 2002, Orlando, FL; Drug Met. Reviews, Vol. 34 (Suppl. 1.) 65, 2002.

"Simultaneous Quantitation of 9-Nitrocamptothecin, an Anticancer Agent, and Its Metabolite, 9Aminocamptothecin, by LC/MS/MS in Rat, Rabbit, and Human Plasma and Human Urine," Z. Gu, X. Zhao, D. Zhou, M. Huo, H. Sands, and J. Wu, The 50th ASMS Conference, Orlando, FL, June 2002.

"A New Liquid Chromatography-Tandem Mass Spectrometry Method (0.1-1,000 ng/mL) for Quantitation of Paclitaxel in Human and Rat Plasma," D. Zhou, G. Zhou, M. Huo, J. Wu, and Z. Gu, The 50th ASMS Conference, Orlando, FL, June 2002.

"Formation of Metal Adduct Solvent Ions or Ion Clusters and their Influence on LC/MS Analysis," Z. Gu, D. Zhou, X. Zhao, and J. Wu, The 50th ASMS Conference, Orlando, FL, June 2002.

"Enhancement of SCH 211803 ESI/LCMS Metabolite Identification in Mouse and Rat Bile by the Removal of Matrix-Induced Ion Supression," Iannucci, R.M., Achanfuo-Yeboah, J., Kaczynski, E.J., Ramaiya, A., Chowdhurry, S.K., Stauber, K.L., Gu, Z., Alton, K.B., and Patrick, J.E., The 50th ASMS Conference, Orlando, FL, June 2002.

"Studies on rosiglitazone maleate intragastric floating sustainedreleased tablet," Feng, H., Wang, Z., and Chen, D., Journal of China Pharmaceutical University, 33(3): 196-199, 2002.

"A review on interaction of Compatibility of medicine and traditional Chinese medicine," Feng, H. and Wang, Z., Chinese Journal of Experimental Traditional Medical Formulae, 8(2): 53-55, 2002.

"Determination of Emamectin Residues in the Tissues of Atlantic Salmon (Salmo salar L.) Using HPLC with Fluorescence Detection," H. Kim-Kang, L.S. Crouch, A. Bova, R.A. Robinson, and J. Wu, J. Agric. and Food Chem., 49(11): 5294-5302, 2001.

"LC/MS/MS Quantification of 9-Nitrocamptothecin and 9-Aminocamptothecin in Dog Plasma Using Atmospheric Pressure Chemical Ionization or Electrospray Ionization Methods," O. Timofeev, H. Usansky, Z. Gu, I. Segarra, H. Sands, P.J. Sinko, and T.J. Cook, 2001 AAPS Annual Meeting, Denver, CO, October 2001.

"Biotransformation of [14C] BMS-184476 in Bile-Duct Cannulated (BDC) Rats," N. Comezoglu, D.W. Everett, S. Lan, Z. Gu, S. Bonacorsi, M. Ogan, and K.J. Kripalani, 2001 AAPS Annual Meeting, Denver, CO, October 2001.

"Keys to Successful Outsourcing Choices," N.J. Lewis, Contract Pharma, Vol. 2, No. 1, 38-43, January/February 2000.

"Pharmacokinetics and Mass Balance of Porfiromycin in the Rat and Dog," J. Mao, W.S. Lang, S. Barrows, B. Almassian, and J. Chemidlin, 1999 AAPS Annual Meeting, New Orleans, LA, November 1999, Abstract No. 1087.

"The Disposition of a Single Dose of 14C OPC-41061 in Healthy Male Volunteers," B.K. Tammara, K. Sekar, and S.L. Bramer, 1999 AAPS Annual Meeting, New Orleans, LA, November 1999, Abstract No. 2025.

"Quantitative Evaluation of Annonaceous Acetogenins in Monthly Samples of Paw Paw (Asimina triloba) Twigs by Liquid Chromatography/Electrospray Ionization/Tandem Mass Spectrometry," Z. Gu, D. Zhou, N.J. Lewis, J. Wu, H.A. Johnson, J.L. McLaughlin, and J. Gordon, Phytochemical Analysis, 10, 32-38, 1999.

"Chemical Defense in the Zebra Swallowtail Butterfly, Eurytides marcellus, Involving Annonaceous Acetogenins," J.M. Martin, S.R. Madigosky, Z. Gu, D. Zhou, J. Wu, and J.L. McLaughlin, J. Nat. Prod, 62, 2-4, 1999.

"Aged Soil Column Leaching of Emamectin Benzoate (MAB1a)," J.S. O'Grodnick, P.G. Wislocki, J.L. Reynolds, M. Wisocky, and R.A. Robinson, J. Agric. Food Chem., 46, 2044-2048, 1998.

"A Sensitive and Specific Chiral LC-MS/MS Method for Quantitative Analysis of Low Levels of Enantiomers of OPC-29030 in Human Plasma and Urine," J. Wu, P. Tata, Z. Gu, and S. Bramer, 1998 AAPS Annual Meeting, San Francisco, CA, November 1998.

"Development and Validation of a Determinative Method for the Analysis of Flunixin in Bovine Liver," R.A. Robinson, D.D.W. Liu, M. Wisocky, A.M. Bova, and R.P. Clement, 1998 AAPS Annual Meeting, San Francisco, CA, November 1998.

"Development and Validation of a Method for the Quantitative Determination of OPC-41061 and its Metabolites by LC-MS/MS," K. Sekar, Z. Gu, P.N.V. Tata, D. Zhou, and S. Bramer, 1998 AAPS Annual Meeting, San Francisco, CA, November 1998.

"A Sensitive and Specific LC-MS/MS Method for the Analysis of OPC-29030 and Ten Metabolites in Human Plasma and Urine," Z. Gu, P.N.V. Tata, D. Zhou, R.R. Abbas, J. Wu, N.J. Lewis, and S. Bramer, 1998 AAPS Annual Meeting, San Francisco, CA, November 1998.

"Fate of [14C]Diphenylamine in Stored Apples," H. Kim-Kang, R.A. Robinson, and J. Wu, J. Agric. Food Chem., 46, pp. 707-717, 1998.

"Reversal effect of Ys-96, a bisbenzylisoquinoline, on Adriamycine or Vincristine Resistance in human cancer cellsin Vitro," Ye, Z., Sun, A., Li, C., Xue, B., Wang, Z., Tong, Y., Feng, H., et. al., China Journal of Chinese Materia Medica, 23(7): 427-428, 1998.

"High-Throughput Pharmacokinetics in Support of Drug Discovery: Pharmacokinetic Testing of Pools of NSubstituted Glycines in Mice," C.M. Dietz, H. Luo, Z-P. Luo, Z. Gu, J. Wu, D. Zhou, R.A. Braeckman, and J.A., Gibbons, Pharmaceutical Research, 14, Abstract No. 2566, p. S-397, 1997.

"Absolute Stereochemistry of DPI-3290W93: A New Multichiral Opioid Analgesic with Reduced Respiratory Depression," D.D.W. Liu, S.N. Comezoglu, K-J. Chang, H.O. Pettit, and N.J. Lewis, Pharmaceutical Research, 14, Abstract No. 4260, p. S-694, 1997.

"On-line Coupling of In Vivo Rat Biliary Elimination and Pharmacokinetics with Liquid Chromatograhy/Mass Spectrometry (LC/MS)," J. Wu, Z. Gu, J. Chemidlin, Z. Liang, D. Wu, N.J. Lewis, S. Smith, and D.A. Hawkins, American Chemical Society, 213th National Meeting, April 13-17, 1997.

"Development of HPLC Methods for Assessment of Epimeric Impurities in DP-3290W93: A New Opioid Analgesic with Three Chiral Centers," D.D.W. Liu, S.N. Comezoglu; A. Hussain, K-J. Chang, H.O. Pettit, J.Wu, and N.J. Lewis, Pharmaceutical Research, 14, Abstract No. 4169, p. S-686, 1997.

"Screening for Annonaceous Acetogenins in Bioactive Plant Extracts by Liquid Chromatography/Mass Spectrometry," Z. Gu, D. Zhou, J. Wu, G. Shi, L. Zeng, and J.L. McLaughlin, J. Natural Products, 60, pp. 242-248, 1997.

"Isolation of New Bioactive Annonaceous Acetogenins from Rolling mucosa Guided by Liquid Chromatography/ Mass Spectrometry," Z. Gu, D. Zhou, N.J. Lewis, J. Wu, G. Shi, and J.L. McLaughlin, Bioorganic and Medicinal Chemistry, 5, pp. 1911-1916, 1997.

"Metabolism of [14C]Cypermethrin in Sugar Beet," S.N. Comezoglu, Z. Liang, V.T. Ly, J. Wu, R.A. Robinson, M. George, J.H. Finley, and L.W. Froelich, American Chemical Society, 212th National Meeting, August 1996.

"Degradation of [14C]Propargite in Soil," S.N. Comezoglu, V.T. Ly, J. Wu, W.H. Harned, D.G.Dzialo, and C.K.White, American Chemical Society, 211th National Meeting, March 1996.

"On-line Coupling on In Vivo Rat Biliary Elimination and Pharmacokinetics with Liquid Chromatography/Mass Spectrometry," Z. Liang, D. Wu, J. Accatatta (Chemidlin), and J. Wu, Mid-Atlantic Pesticide Discussion Group, Spring Meeting, 1996.

"Metabolic Fate of Oxyfluorfen in Laying Hens," H. Kim-Kang, J.P. Hogya, J.D. Smalley, R.A. Robinson, J. Wu, Q. Zhang, P. Reibach, and B.P. Chong, American Chemical Society, 207th National Meeting, March 1994.

"A Comparison of Radioactivity Detection Methods Available for Thin-Layer Chromatography," D. Hawkins, J. Wu, J. Ryan, and R. Weintraub, Mid-Atlantic Pesticide Metabolism Discussion Group, February 1993.

"The Aqueous Photolysis of 14C-Oxyfluorfen Following Irradiation with a Xenon Light Source," P.H. Reibach, D.E. Karr, J.L. Reynolds, and J. Wu, American Chemical Society, 204th National Meeting, August 1992.

"Metabolic Fate of Mevinphos in the Lactating Goat," J. Wu, D.D.W. Liu, R.A. Robinson, E.M. Craine, and D.I. Wang, American Chemical Society, 204th National Meeting, August 1992.

"Ametryn in Rats, Lactating Goats, and Laying Hens-Metabolic Fate," J. Wu, D.D.W. Liu, R.A. Robinson, W. Itterly, and T.M. Capps, Chapter 12, pp. 168-189, Xenobiotics and Food Producing Animals-Metabolism and Residues, American Chemical Society Symposium Series 503, 1992.

"Maduramicin: Characterization of 14C-Derived Residues in Turkey Excreta," S.J. Stout, J. Wu, A.R. daCunha, K.G. King, and A-H-Lee, J Agric. Food Chem., 39, p.386, 1991.

"Metabolic Fate of Ametryn in Rats, Lactating Goats and Laying Hens," J. Wu, D.D.W. Liu, and R.A. Robinson, American Chemical Society, 202nd National Meeting, August 1991.

"The Metabolism of Pentachloronitrobenzene (PCNB) in Mature Field Grown Peanuts, Cabbage, and Potatoes" J.E. Cassidy, D. Liu, and J. Wu, Gordon Conference, 1990.