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Wednesday, November 22, 2017

Posters

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A Sensitive Liquid Chromatogram/Mass Spectrometry Method for the Determination of a Therapeutic siRNA in Human Plasma. Presented at the American Society for Mass Spectrometry 64th ASMS Conference, San Antonio, Texas, June 5 - 9 2016.

Absorption, distribution, metabolism, and excretion of [14C]-dasotraline in Humans. Published in Pharmacology Research and Perspectives, Volume 5, Issue 1, e00281.

A Sensitive LC-MS/MS Method for Quantitation of Naltrexone and 6ß-Naltrexol in Human Plasma (1 pg/mL). Presented at the American Society for Mass Spectrometry 64th ASMS Conference, San Antonio, Texas, June 5 - 9 2016.

Novel Approach to Minimize the Matrix Effect in the Development of LC-MS/MS Method for Quantitation of Buprenorphine and Norbuprenorphine in Human Urine. Presented at the American Society for Mass Spectrometry 64th ASMS Conference, San Antonio, Texas, June 5 - 9 2016.

Different Approach for Improvement of Low Recovery Dried Blood Spot Storage Sample and Its Application in BioanalyticalAssay. Presented at the American Society for Mass Spectrometry 64th ASMS Conference, San Antonio, Texas, June 5 - 9 2016.

Species-Specific Red Blood Cell Partitioning of a Test Drug: Elucidation of the Selective Binding to Rat β2 Globin of a Test Drug. Presented at the 11th International ISSX Meeting, Busan, Korea, June 2016.

Total Residue Depletion and Metabolism of [2-14C]Enrofloxacin in the Milk of Lactating Dairy Cows. Presented at the 11th International ISSX Meeting, Busan, Korea, June 2016.

Analytical Method for the Determination of a Major Residue with a Zwitterionic nature of a Fluoroquinolone Antimicrobial Drug in Bovine Milk using with Fluorescence Detection. Presented at the 20th North American ISSX Meeting, Orlando, FL, October 2015.

Significant Sulfate Metabolite Fomration of WX-1 Ex Vivo with Human K2EDTA blood, Minor in Human Na-Heparin Blood and Human K2EDTA Plasma, and Absent in Rat or Dog K2EDTA Plasma and Blood. Presented at the 20th North American ISSX Meeting, Orlando, FL, October 2015.

Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites withthe BACE1 Inhibitor GNE-892 in Rats. 2015.

A Sensitive LC-MS/MS Method for Quantitation of Buprenorphine and Norbuprenorphine in Human Plasma. Presented at the ASMS Meeting, 2015.

A Sensitive LC-MS/MS Method for Quantitation of Digoxin (10 pg/mL) in Human Plasma. Presented at the ASMS Meeting, 2015.

A Novel LC-MS/MS Method for Quantitation of GLS409 in Rat Plasma. Presented at the ASMA Meeting, 2015.

A Sensitive LC-MS/MS Method for Quantitation of 7α-hydroxy-4-cholesten-3-one in Human Plasma. Presented at the ASMA Meeting, 2015.

Quantitative Whole Body Autoradiography (QWBA) Analysis Reveals that CPX-351 Shifts the Exposure of Cytarabine (Cyt) and Daunorubicin (Daun) Away from Many Tissues While Providing Prolonged Exposure to Cytotoxic Drug Concentrations in the Bone Marrow Compared to Conventional Free Drug Administration. Presented at the 56th ASH Meeting, San Francisco, CA, December 2014.

CPX-351 Markedly Reduces Renal and Hepatic Clearance Rates for Cytarabine (Cyt) and Daunorubicin (Daun) in Rats with an Associated Decrease in Excretory and Metabolic Burden Despite Providing Dramatic Increases in Systemic Drug Exposure Compared to Conventional Cyt+Daun. Presented at the 56th ASH Meeting, San Francisco, CA, December 2014.

In Vivo Rat Metabolism of an Acute Myeloid Leukemia (AML) Drug CPX-351 (Cytarabine:Daunorubicin) Liposome Injection. Presented at the 19th North American ISSX Meeting, San Francisco, CA, October 2014.

A Novel LC-MS/MS Method for Quantitation of Three Fatty Acids in Human Plasma. Presented at the 62nd ASMS Conference, Baltimore, MD, June 2014.

An Extremely Sensitive LC-MS/MS Method for Quantitation of Fluticasone Propionate (0.4 pg/mL) in Human Plasma. Presented at the 62nd ASMS Conference, Baltimore, MD, June 2014.

Application of In-Source Fragmentation for More Accurate Metabolite Semi-quantification by Peak Area from High-Resolution Mass Spectrometry. Presented at the 62nd ASMS Conference, Baltimore, MD, June 2014.

Evaluation of 4B-Hydroxycholesterol as an Endogenous Biomarker of CYP3A in Cynomolgus Monkeys. Presented at the 10th International ISSX Meeting, Toronto, ON, Canada, October 2013.

In Vivo Rat Metabolism of an Obesity Drug Beloranib. Presented at the 10th International ISSX Meeting, Toronto, ON, Canada, October 2013.

Unique Biotransformation from Pyrimidine to Pyrazole Derivatives in Rats - Its Isolation/Identification by LC/MS and NMR.  Presented at the 18th Annual North American Regional ISSX Meeting, Dallas, TX, October 2012.

Assessing Metabolite Coverage of LY2608204 Human Metabolites in Chronic Rat and Dog Toxicology Studies.  Presented at the 15th Annual Land O' Lakes Conference, Merrimac, WI, Sept. 10-14, 2012.

An Ultra Sensitive LC-MS/MS Method for Quantitation of Salmeterol (LLOQ, 0.5 pg/ML) in Human Plasma.  Presented at the APA Conference, Baltimore, MD, Sept. 2012.

Application of In-Source Fragment Ion Filtering in Drug Metabolite Profiling and Identification by High-Resolution Mass Spectrometry, Presented at the 60th ASMS Conference, Vancouver, Canada, May 2012.

A Sensitive LC-MS/MS Method for the Quantitation of Fluticasone Propionate (1 pg/mL) in Human Plasma, Presented at the 60th ASMS Conference, Vancouver, Canada, May 2012.

Disposition, Metabolism and Mass Balance of [14C] Apremilast, a Novel PDE4 Inhibitor, Following Oral Administration, Presented at the Society of Investigative Dermatology, Phoenix, AZ, May 7, 2011.

Investigation of SEP-227900 metabolites in Humans from the First-in-Man Study Samples by LC-MS and NMR, Presented at the 2011 AAPS Annual Meeting, Washington, DC, October 2011.

Identification and Determination of the Percent AUC of Five Metabolites of a Tetrahydropyran-containing Drug, Co-eluting as a Broad Peak due to the Presence of Metabolites Undergoing Conformational Change during HPLC Radiochromatography, Presented at the 17th Annual North American Regional ISSX Meeting, Atlanta, GA, October 2011.

Investigation of Incurred Sample Reanalysis Failure in Sample Analysis for Human Urine P-Aminohippuric Acid and Metformin, Presented at the 12th Annual Land O' Lakes Bioanalytical Conference, Madison, WI, July 2011.

An LC-MS/MS Method for Simultaneously Determining Formoterol and Budesonide in Human Plasma with Dual HPLC System, Presented at the 59th ASMS Conference, Denver, CO, June 2011.

Validation of A Surrogate Derivative LC/MS/MS Method for the Determination of Glucose in Human Plasma with [13C6] D-Glucose as a Tracer, Presented at the 59th ASMS Conference, Denver, CO, June 2011.

Comparative in vitro Metabolism of Benzyl Amine Containing Test Drug Using Human, Rat, and Dog Plasma – Investigation of Amine Oxidase Involvement in Drug Metabolism, Presented at the 9th International ISSX Meeting, Istanbul, Turkey, September 2010.

Application of 19F NMR to Mass Balance Studies, Presented at the 9th International ISSX Meeting, Istanbul, Turkey, September 2010.

Mass Defect Filtering: a New Tool to Expedite Screening, Dereplication and Identification of Natural Products, Presented at The 58th ASMS Conference, Salt Lake City, UT, May 2010.

A Selective and Sensitive LC-MS/MS Method for the Determination of Beclomethasone Dipropionate and Beclomethasone-17-Propionate in Human Plasma, Presented at The 58th ASMS Conference, Salt Lake City, UT, May 2010.

Accurate Measurement of Biopolymer Molecular Weight with Orbitrap Mass Spectrometer, Presented at The 58th ASMS Conference, Salt Lake City, UT, May 2010.

Metabolism and Excretion of PRT060128, a New Competitive, Reversible P2Y12 Inhibitor, in Healthy Human Subjects, Presented at the 2008 AAPS Annual Meeting, Atlanta, GA, November 2008.

Structural Determination of By-Products Obtained in Acetylation of Cysteine and Cysteine-Conjugated Metabolites by LTQ-Orbitrap XL � Leading to the Establishment of an Alternative Esterification and Amidation Method, Presented at The 57th ASMS Conference, Philadelphia, PA, June 2009.

A Sensitive LC-MS/MS Method for the Determination of KX2-391 in Human Plasma, Presented at The 57th ASMS Conference, Philadelphia, PA, June 2009.

A Rapid LC-MS/MS Method for the Determination of Telbivudine in Human Plasma, The 57th ASMS Conference, Philadelphia, PA, June 2009.

Quantification of a Polypeptide Drug, Desirudin, in Human PlasmaUsing Electrospray LC-MS/MS with an Analog Polypeptide as Internal Standard, Presented at The 56th ASMS Conference, Denver, CO, June 2008.

Comprehensive Investigation of Injection Time and Auto Gain Control on Ion Trap Instruments for LC/MS Application of Metabolite Identification, Presented at The 56th ASMS Conference, Denver, CO, June 2008.

A Rapid and High Sensitive LC-MS/MS Method for Quantitation of Budesonide in Human Plasma, Presented at The 56th ASMS Conference, Denver, CO, June 2008.

A Sensitive LC-MS/MS Method for Quantitation of Ribavirin in Human Plasma, Presented at The 56th ASMS Conference, Denver, CO, June 2008.

A High Sensitive LC-MS/MS Method for Quantitation of Formoterol in Human Plasma, Presented at The 56th ASMS Conference, Denver, CO, June 2008.

Automatic Generation of Extract ion Chromatogram for Mass Spectral Peaks with Specific Isotope Labeled Patterns, Presented at The 55th ASMS Conference, Indianapolis, IN, June 2007.

Mass Balance, Metabolism, and Excretion of Rambazole, a Novel Retinoic Acid Metabolism-Blocking Agent (RAMBA) in Mice, Rats, and Dogs, Presented at The 14th North American ISSX Meeting, Puerto Rico, October, 2006.

Sensitive and Rapid Method for the Determination of (R,R)-Formoterol and (S,S)-Formoterol in Human Plasma Using Chiral Liquid Chromatography-Tandem Mass Spectrometry, Presented at the 2006 AAPS Annual Meeting, San Antonio, TX, October 2006.

Determination of In Vivo Chiral Inversion of (R,R)-Formoterol to its Stereosiomers, (S,S)-Formoterol, (R,S)-Formoterol, and (S,R)-Formoterol, by Highly Sensitive and Specific LC/MS/MS Methods in Human Plasma Presented at the G., New England Drug Metabolism Discussion Group Summer Symposium, June, 2006.

Automated and Parameter-Free Peak Integration for LC/MS/MS Quantitation, Gu, M., Zhou, D., Gu, Z.M., and Wang, Y., presented at the 54th ASMS Conference, Seattle, WA, May 2006.

 LC/MS Chiral Methods and Its Application in Bioanalysis, Presented at The 54thASMS Conference, Seattle, WA, May 2006.

 Reduction of nitriles to amines in positive ion electrospray ionization mass spectrometry, Presented in Rapid Communications in Mass Spectrometry, 20: 2969-2972, 2006.

A Highly Sensitive and Specific LC/MS/MS Method for Quantitation of Methotrexate and Its 7-Hydroxy Metabolite in Human Plasma, Presented at The 54th ASMS Conference, Seattle, WA, May 2006.

A New LC/MS/MS Method for Quantitation of Moxifloxacin in Human Plasma, Presented at the The 54th ASMS Conference, Seattle, WA, May 2006.

In Vitro Metabolism of 14C-Ciclesonide in Hepatocytes from Mice, Rats, Rabbits, Dogs and Humans
Presented at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, November, 2004, Baltimore MD.

Pharmacokinetics, Metabolism, and Excretion of Ciclesonide after Intravenous and Oral Administration of 14C-Ciclesonide in Mice, Rats, Rabbits and Dogs
Presented at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, November, 2004, Baltimore, MD.

Loss of Hydroxyl Radical (�OH) in CAD MD/MS for Identification of Oxidized Drug Metabolites
Presented at the American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry, May, 2004, Nashville TN.

A Highly Sensitive and Specific LC/MS/MS Method (0.5 pg/mL) for Quantitation of (R,R)/(S,S)-Formoterol and (R,S)/(S,R)-Formoterol in Human Plasma and Urine
Presented at the American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry, May, 2004, Nashville TN.

Tissue Distribution, Metabolism and Residue Depletion Study in Atlantic Salmon Following Oral Administration of 3H-SCH 58854
Presented at the International Society for the Study of XenoBiotics (ISSX) 12th North American Meeting, October, 2003, Providence, RI.

Determination of (R,R)-Formoterol Inversion Products in Human Plasma and Urine By Chiral and Achiral-LC/MS/MS
Presented at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, October, 2003, Salt Lake City, UT.

Mass Balance Study of 14C-Nebivolol in Humans with Different CYP2D6 Genotypes
Presented at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, October, 2003, Salt Lake City, UT.

Metabolism Study of 14C-Nebivolol in Humans with Different CYP2D6 Genotypes
Presented at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, October, 2003, Salt Lake City, UT.

A Highly Sensitive and Specific LC/MS/MS Method (3 pg/mL) for Quantitation of Fluticasone Propionate in Human Plasma
Presented at the American Society for Mass Spectrometry (ASMS) 51st Conference on Mass Spectrometry, June, 2003, Montreal, QC.

Simultaneous Determination of the Enantiomers of Ketorolac as well as XBL011003 in Human Plasma with LC/MS
Presented at the American Society for Mass Spectrometry (ASMS) 51st Conference on Mass Spectrometry, June, 2003, Montreal, QC.

Simultaneous Quantitation of 9-Nitrocamptothecin an Anticancer Agent, and its Metabolite, 9-Aminocamptothecin by LC/MS/MS in Rat, Rabbit, and Human Plasma and Human Urine
Presented at the American Society for Mass Spectrometry (ASMS) 51st Conference on Mass Spectrometry, June, 2002, Orlando, FL.

A New Liquid Chromatography-Tandem Mass Spectrometry Method (0.1-1,000 ng/mL) for Quantitation of Paclitaxel in Human and Rat Plasma
Presented at the American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry, June, 2002, Orlando, FL.

Formation of Metal Adduct Solvent Ions or Ion Clusters and the Influence on LC/MS Analysis
Presented at the American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry, June, 2002, Orlando, FL