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Friday, April 20, 2018

Webinar: Advanced Techniques in Quantitative Whole Body Autoradiography (QWBA), Cryo-imaging and Enhanced 3D modeling

Presented by Stefan Linehan, Manager Preclinical Services at XenoBiotic Laboratories

Original Air Date:  03/22/2012

Quantitative whole body autoradiography (QWBA) is widely used to provide quantitative tissue distribution data of derived radioactivity from a radiolabeled test article as part of a non-clinical ADME program.  QWBA entails acquiring thin sections (entire carcass and/or individual tissues) and determining the radioactive equivalent concentration of the test article in different regions of interest (ROI) within each section.

Advancements within the field of Cryo-imaging and Quantitative Autoradiography (CIQA) along with 3D modeling techniques provide an innovative approach for observing the site specific localization of radioactivity and drug-induced or naturally occurring abnormalities. These developments facilitate insight into the relationship between abnormalities and drug distribution, which can further expand to modeling toxicological or pharmacological findings.

These advancements in CIQA can be similarly used to provide useful information in the fields of oncology (tumor modeling), and neurology.

Examples of CIQA were presented and compared to non-invasive pre-clinical imaging techniques.


Who Will Benefit?

Many industrial, academic and regulatory scientists, whether you are just getting started or a seasoned veteran, will gain a practical understanding of new developments in QWBA and cryo-imaging techniques and how they can be applied to aid drug development, including:

• Clinical Pharmacokineticists
• Non-clinical ADME/DMPK scientists
• Drug metabolism scientists
• Regulatory submissions personnel
• Toxicologists
• Clinical pharmacologists
• Oncologists
• Neuroscientists





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